Science Fiction and Horror are cousins—creepy, often slimy cousins. Cousins with pustules, often.

There are so many utterly brilliant options to pick through that our omissions are bound to frustrate and upset, but whether your horror comes from the lab, from space or from the space/time continuum, when you watch these five, your neighbors will hear you scream.

5. Invasion of the Body Snatchers (1956)

Director Dono Siegel was the first filmmaker to bring Jack Finney’s Cold War nightmare to the screen. He wouldn’t be the last, maybe not even the best, but what he did with this eerie alien tale tapped into a societal anxiety and quickly became one of the most influential and terrifying films of its time.

Doc Miles Bennell (Kevin McCarthy) is just home from a short trip when he’s inundated by patients swearing their loved ones are not their loved ones at all. Sure, they look the same and have all the same skills and memories, but there’s no warmth, no passion.

With this, the fear that our very nation could be overtaken by an outside force – Russians, say, for terrifyingly immediate sake of argument – working its way through not by force, but by quietly taking over each and every person in one town, then spreading from town to town to town.

It’s the kind of insidious evil that fuels contagion horror, infestation horror, even demonic horror. But Invasion of the Body Snatchers spoke to a society’s deepest fears and became a touchstone for all SciFi to follow it.

4. The Fly (1986)

After a couple of interesting, if un-medical films, the great David Cronenberg made a triumphant return to the laboratory of the mad scientist in his most popular film to date.

But it’s not just Cronenberg’s disturbed genius for images and ideas that makes The Fly fly; it’s the performance he draws from Jeff Goldblum.

Goldblum is an absolute gift to this film, so endearing in his pre-Brundlefly nerdiness. He’s the picture’s heartbeat, and it’s more than the fact that we like his character so much. The actor also performs heroically under all those prosthetics.

He and Geena Davis make the perfect pair, with their matching height and mullets, and their onscreen chemistry does give the film a level of human drama traditionally lacking from the Cronenberg canon. Atop that, there’s the transformation scene in the bathroom – the fingernails, the pustules – all classic Cronenberg grotesquerie, and still difficult to watch.

https://www.youtube.com/watch?v=7BzwxJ-M_M0

3. Timecrimes (2007)

This one is nutty, and absolutely required viewing for anyone with an interest in space/time continuum conundrums.

Writer/director/co-star Nacho Vigalondo (Colossal) mocks our desire for control and our fear of the doppelganger with a very quick and dirty trip through time. So much can go wrong when you travel just one hour backward. The less you know going in, the better.

An always clever experiment in science fiction, horror and irony, Timecrimes is a spare, unique and wild ride.

2. The Thing (1982)

John Carpenter’s remake of the 1951 SciFi flick The Thing from Another World concocts a thoroughly spectacular tale of icy isolation, contamination, and mutation.

A beard-tastic cast portrays a team of scientists on expedition in the Arctic who take in a dog. The dog is not a dog, though. Not really. And soon, in an isolated wasteland with barely enough interior room to hold all the facial hair, folks are getting jumpy because there’s no knowing who’s not really himself anymore.

This is an amped up body snatcher movie benefitting from some of Carpenter’s most cinema-fluent and crafty direction: wide shots when we need to see the vastness of the unruly wilds; tight shots to remind us of the close quarters with parasitic death inside.

The story remains taut beginning to end, and there’s rarely any telling just who is and who is not infected by the last reel. You’re as baffled and confined as the scientists.

1. Alien (1979)

Director Ridley Scott’s other masterpiece, Alien, traps a crew aboard a rickety, dark, workingman’s spacecraft with the coolest monster perhaps ever.

After a vagina-hand-sucker-monster attaches itself to your face, it gestates inside you, then tears through your innards. Then it grows exponentially, hides a second set of teeth, and bleeds acid. How much cooler could this possibly be?

Compare that to the crew, and the competition seems unreasonably mismatched. The sunken-chested Harry Dean Stanton, the screechy Veronica Cartwright, the sinister Ian Holm, the mustachioed Tom Skerritt, even the mulleted Sigourney Weaver – they all seem doomed before we even get to know them.

Much ado has been made, rightfully so, of the John Hurt Chest Explosion (I loved their early work, before they went commercial). But Scott’s lingering camera leaves unsettling impressions in far simpler ways, starting with the shot of all those eggs.